Publications
⌘ Elastic dosage compensation by X-chromosome upregulation
Lentini A, Cheng H, Noble JC, Papanicolaou N, Coucoravas C, Andrews N, Deng Q, Enge M, & Reinius B#.Nature Communications. 2022; https://www.nature.com/articles/s41467-022-29414-1Detection and isolation of airborne SARS‐CoV‐2 in a hospital setting
de Sousa NR, Steponaviciute L, Margerie L, Nissen K, Kjellin M, Reinius B, Salaneck R, Udekwu KI, Rothfuchs AG#.Indoor Air. 2022; http://dx.doi.org/10.1111/ina.13023Transcriptional kinetics and molecular functions of long noncoding RNAs
Johnsson P, Ziegenhain C, Hartmanis L, Hendriks GJ, Hagemann-Jensen M, Reinius B & Sandberg R#.Nature Genetics. 2022; https://www.nature.com/articles/s41588-022-01014-1Cheng H, Pui H, Lentini A, Kolbeinsdóttir S, Andrews, Pei Y, Reinius B, Deng Q, Enge M#.biorXiv. 2021; doi: https://doi.org/10.1101/2021.12.02.470912
Lentini A, Cheng H, Noble JC, Papanicolaou N, Coucoravas C, Andrews N, Deng Q, Enge M, Reinius B#.biorXiv. 2021; doi: https://doi.org/10.1101/2021.07.14.452323
Mold JE, Modolo L, Hård J, Zamboni M, Larsson AJM, Stenudd M, Eriksson CJ, Durif G, Ståhl PL, Borgström E, Picelli S, Reinius B, Sandberg R, Réu P, Talavera-Lopez C, Andersson B, Blom K, Sandberg JK, Picard F, Michaëlsson J, Frisén J#.Cell Reports.. 2021; doi: https://doi.org/10.1016/j.celrep.2021.109174
Transcriptional bursts explain autosomal random monoallelic expression and affect allelic imbalance
Larsson AJM, Ziegenhain C, Hagemann-Jensen M, Reinius B, Jacob T, Dalessandri T, Hendriks GJ, Kasper M, Sandberg R#PLOS Computational Biology. 2021; doi: https://doi.org/10.1371/journal.pcbi.1008772Strunz B, Bister J, Jönsson H, Filipovic I, Crona-Guterstam Y, Kvedaraite E, Sleiers N, Dumitrescu B, Brännström M, Lentini A, Reinius B, Cornillet M, Willinger T, Gidlöf S, Hamilton RS, Ivarsson MA, Björkström NK#Science Immunology. 2021; doi: https://doi.org/10.1126/sciimmunol.abb7800
Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples
Alekseenko A, Barrett D, Pareja-Sanchez Y, Howard R, Strandback E, Ampah-Korsah H, Rovšnik U, Zuniga-Veliz S, Klenov A, Malloo J, Ye S, Liu X, Reinius B, Elsässer S, Nyman T, Sandh G, Yin X, Pelechano V#.Scientific Reports. 2021; doi: https://doi.org/10.1038/s41598-020-80352-8⌘ Massive and rapid COVID-19 testing is feasible by extractionfree SARS-CoV-2 RT-PCR
Smyrlaki I*, Ekman M*, Lentini A, Rufino de Sousa N, Papanicolaou N, Vondracek M, Aarum J, Safari H, Muradrasoli S, Rothfuchs AG, Albert J2,3, Högberg B, Reinius B#.Nature Communications. 2020; https://doi.org/10.1038/s41467-020-18611-5 (First published as preprint at medRxiv.org, online April 17th, 2020)Natural killer cell immunotypes related to COVID-19 disease severity
Maucourant C, Filipovic I, Ponzetta A, Aleman S, Cornillet M, Hertwig L, Strunz B, Lentini A, Reinius B, Brownlie D, Gomez AC, Ask EH, Hull RM, Haroun-Izquierdo A, Schaffer M, Klingstrom J, Folkesson E, Buggert M, Sandberg JK, Eriksson LI, Rooyackers O, Ljunggren HG, Malmberg KJ, Michaelsson J, Marquardt N, Hammer Q, Stralin K, Bjorkstrom NK#Karolinska COVID-19 Study Group.Science Immunology. 2020; doi: https://doi.org/10.1126/sciimmunol.abd6832⌘ X-chromosome upregulation is dynamically linked to the X-inactivation state
Lentini A, Enge M, Deng Q, Reinius B#.bioRxiv. 2020; doi: https://doi.org/10.1101/2020.07.06.189787⌘ X-chromosome upregulation is driven by increased burst frequency
Larsson AJM, Coucoravas C, Sandberg R, Reinius B#.Nature Structural & Molecular Biology. 2019; doi: 10.1038/s41594-019-0306-yAn an excellent News & Views piece on this study featured in the same journal issue, and is available here: Rapid transcriptional bursts upregulate the X chromosome, by Xinxian Deng & Christine M. Disteche.Link to open access version (postprint) here. Reinius B# and Sandberg R#.bioRxiv. 2019, 682286; doi: 10.1101/682286Transcriptional kinetics of X-chromosome upregulation
Larsson AJM , Coucoravas C, Sandberg R, Reinius B#.bioRxiv. 2019, 540104; doi: 10.1101/540104Cheng S, Pei Y, He L, Peng G, Reinius B, Tam PPL, Jing N, Deng Q#. Cell Reports. 2019 Mar 5;26(10):2593-2607.e3. doi: 10.1016/j.celrep.2019.02.031.PubMed PMID: 30840884
⌘ Genomic encoding of transcriptional burst kinetics
Larsson AJM, Johnsson P, Hagemann-Jensen M, Hartmanis L, Faridani OR, Reinius B, Segerstolpe Å, Rivera CM, Ren B, Sandberg R#. Nature. 2019 Jan;565(7738):251-254. doi: 10.1038/s41586-018-0836-1. Epub 2019 Jan 2. PubMed PMID: 30602787Reply to 'High prevalence of clonal mono allelic expression'
Reinius B, Sandberg R#.Nature Genetics. 2018 Sep;50(9):1199-1200. doi: 10.1038/s41588-018-0189-6.PubMed PMID: 30082784.Vértesy Á, Arindrarto W, Roost MS, Reinius B, Torrens-Juaneda V, Bialecka M, Moustakas I, Ariyurek Y, Kuijk E, Mei H, Sandberg R, van Oudenaarden A#, Chuva de Sousa Lopes SM#.Nature Communications. 2018 May 14;9(1):1873. doi: 10.1038/s41467-018-04215-7.PMID: 29760424
Comparative Analysis of Single-Cell RNA Sequencing Methods
Ziegenhain C, Vieth B, Parekh S, Reinius B, Guillaumet-Adkins A, Smets M, Leonhardt H, Heyn H, Hellmann I, Enard W#.Molecular Cell. 2017 Feb 16;65(4):631-643.e4. doi: 10.1016/j.molcel.2017.01.023.PMID: 28212749⌘ Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq
Reinius B*, Mold JE*, Ramsköld D, Deng Q, Johnsson P, Michaëlsson J, Frisén J, Sandberg R#.Nature Genetics. 2016 Nov;48(11):1430-1435. doi: 10.1038/ng.3678. Epub 2016 Sep 26.PMID: 27668657scphaser: haplotype inference using single-cell RNA-seq data
Edsgärd D, Reinius B, Sandberg R#.Bioinformatics. 2016 Oct 1;32(19):3038-40. doi: 10.1093/bioinformatics/btw484. Epub 2016 Aug 6.PMID: 27497440Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation
Chen G, Schell JP, Benitez JA, Petropoulos S, Yilmaz M, Reinius B, Alekseenko Z, Shi L, Hedlund E, Lanner F, Sandberg R, Deng Q#.Genome Research. 2016 Oct;26(10):1342-1354. Epub 2016 Aug 2.PMID: 27486082⌘ Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos
Petropoulos S*, Edsgärd D*, Reinius B*, Deng Q, Panula SP, Codeluppi S, Plaza Reyes A, Linnarsson S, Sandberg R#, Lanner F#.Cell. 2016 May 5;165(4):1012-26. doi: 10.1016/j.cell.2016.03.023. Epub 2016 Apr 7.PMID: 27062923Reinius B, Sandberg R#.Nature Reviews Genetics. 2015 Nov;16(11):653-64. doi: 10.1038/nrg3888. Epub 2015 Oct 7. Review.PMID: 26442639
Mondal T, Subhash S, Vaid R, Enroth S, Uday S, Reinius B, Mitra S, Mohammed A, James AR, Hoberg E, Moustakas A, Gyllensten U, Jones SJ, Gustafsson CM, Sims AH, Westerlund F, Gorab E, Kanduri C#.Nature Communications. 2015 Jul 24;6:7743. doi: 10.1038/ncomms8743.PMID: 26205790
Conditional targeting of medium spiny neurons in the striatal matrix
Reinius B, Blunder M, Brett FM, Eriksson A, Patra K, Jonsson J, Jazin E, Kullander K#.Frontiers in Behavioural Neuroscience. 2015 Mar 27;9:71. doi: 10.3389/fnbeh.2015.00071. eCollection 2015.PMID: 25870547Tn5 transposase and tagmentation procedures for massively scaled sequencing projects
Picelli S, Björklund AK, Reinius B, Sagasser S, Winberg G, Sandberg R#.Genome Research. 2014 Dec;24(12):2033-40. doi: 10.1101/gr.177881.114. Epub 2014 Jul 30.PMID: 25079858⌘ Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells
Deng Q*, Ramsköld D*, Reinius B, Sandberg R#.Science. 2014 Jan 10;343(6167):193-6. doi: 10.1126/science.1245316.PMID: 24408435Elevated expression of H19 and Igf2 in the female mouse eye
Reinius B#, Kanduri C.PLoS One. 2013;8(2):e56611. doi: 10.1371/journal.pone.0056611. Epub 2013 Feb 20.PMID: 23437185RNA-binding protein QKI regulates Glial fibrillary acidic protein expression in human astrocytes
Radomska KJ, Halvardson J, Reinius B, Lindholm Carlström E, Emilsson L, Feuk L, Jazin E#.Human Molecular Genetics. 2013 Apr 1;22(7):1373-82. doi: 10.1093/hmg/dds553. Epub 2013 Jan 15.PMID: 23321059Reinius B#, Johansson MM, Radomska KJ, Morrow EH, Pandey GK, Kanduri C, Sandberg R, Williams RW, Jazin E.BMC Genomics. 2012 Nov 10;13:607. doi: 10.1186/1471-2164-13-607.PMID: 23140559
⌘ Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse
Reinius B#, Shi C, Hengshuo L, Sandhu KS, Radomska KJ, Rosen GD, Lu L, Kullander K, Williams RW, Jazin E.BMC Genomics. 2010 Nov 3;11:614. doi: 10.1186/1471-2164-11-614.PMID: 21047393VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch
Lagerström MC, Rogoz K, Abrahamsen B, Persson E, Reinius B, Nordenankar K, Olund C, Smith C, Mendez JA, Chen ZF, Wood JN, Wallén-Mackenzie A, Kullander K#.Neuron. 2010 Nov 4;68(3):529-42. doi: 10.1016/j.neuron.2010.09.016.PMID: 21040852Prenatal sex differences in the human brain
Reinius B#, Jazin E#.Molecular Psychiatry. 2009 Nov;14(11):987, 988-9. doi: 10.1038/mp.2009.79. No abstract available.PMID: 19851278An evolutionarily conserved sexual signature in the primate brain
Reinius B, Saetre P, Leonard JA, Blekhman R, Merino-Martinez R, Gilad Y, Jazin E#.PLoS Genetics. 2008 Jun 20;4(6):e1000100. doi: 10.1371/journal.pgen.1000100.PMID: 18566661